Title

The Interaction of Polyglutamine Peptides with Lipid Membranes Is Regulated by Flanking Sequences Associated with Huntingtin

Document Type

Article

Publication Date

5-2013

Department

Chemistry

Abstract

Background: Huntington disease (HD) is caused by an expanded polyglutamine (polyQ) domain in huntingtin (htt), leading to aggregation.

Results: Specific flanking sequences adjacent to the polyQ domain modulate htt aggregation on lipid bilayers.

Conclusion: Lipid mediated htt aggregation may lead to membrane dysfunction in HD.

Significance: Flanking sequences may play a role in membrane dysfunction associated with Huntington disease.

Comments

Original version is available from the publisher at: http://www.jbc.org/content/288/21/14993.full