Title
The Interaction of Polyglutamine Peptides with Lipid Membranes Is Regulated by Flanking Sequences Associated with Huntingtin
Document Type
Article
Publication Date
5-2013
Department 1
Chemistry
Abstract
Background: Huntington disease (HD) is caused by an expanded polyglutamine (polyQ) domain in huntingtin (htt), leading to aggregation.
Results: Specific flanking sequences adjacent to the polyQ domain modulate htt aggregation on lipid bilayers.
Conclusion: Lipid mediated htt aggregation may lead to membrane dysfunction in HD.
Significance: Flanking sequences may play a role in membrane dysfunction associated with Huntington disease.
DOI
10.1074/jbc.M112.446237
Recommended Citation
Burke, Kathleen A., Karlina J. Kauffman, Samuel Umbaugh, Shelli L. Frey and Justin Legleiter. “The Interaction of Polyglutamine Peptides with Lipid Membranes Is Regulated by Flanking Sequences Associated with Huntingtin.” The Journal of Biological Chemistry 228.21 (May 2013): 14993-15005.
Comments
Original version is available from the publisher at: http://www.jbc.org/content/288/21/14993.full