The Interaction of Polyglutamine Peptides with Lipid Membranes Is Regulated by Flanking Sequences Associated with Huntingtin
Background: Huntington disease (HD) is caused by an expanded polyglutamine (polyQ) domain in huntingtin (htt), leading to aggregation.
Results: Specific flanking sequences adjacent to the polyQ domain modulate htt aggregation on lipid bilayers.
Conclusion: Lipid mediated htt aggregation may lead to membrane dysfunction in HD.
Significance: Flanking sequences may play a role in membrane dysfunction associated with Huntington disease.
Burke, Kathleen A., Karlina J. Kauffman, Samuel Umbaugh, Shelli L. Frey and Justin Legleiter. “The Interaction of Polyglutamine Peptides with Lipid Membranes Is Regulated by Flanking Sequences Associated with Huntingtin.” The Journal of Biological Chemistry 228.21 (May 2013): 14993-15005.