Effects of Prior Acute Exercise on Circulating Cytokine Concentration Responses to a High-fat Meal

Authors

Josef Brandauer, Gettysburg CollegeFollow
Rian Q. Landers-Ramos, University of Maryland - College Park
Nathan T. Jenkins, University of Maryland - College ParkFollow
Espen E. Spangenburg, University of Maryland - College Park
James M. Hagberg, University of Maryland - College ParkFollow
Steven J. Prior, University of Maryland - BaltimoreFollow

Document Type

Article

Publication Date

8-2013

Department 1

Health Sciences

Abstract

High-fat meal consumption alters the circulating cytokine profile and contributes to cardiometabolic diseases. A prior bout of exercise can ameliorate the triglyceride response to a high-fat meal, but the interactive effects of exercise and high-fat meals on cytokines that mediate cardiometabolic risk are not fully understood. We investigated the effects of prior exercise on the responses of circulating tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), IL-8, leptin, retinol-binding protein 4 (RBP4), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) to a high-fat meal. Ten healthy men were studied before and 4 h after ingestion of a high-fat meal either with or without ~50 min of endurance exercise at 70% of VO2 max on the preceding day. In response to the high-fat meal, lower leptin and higher VEGF, bFGF, IL-6, and IL-8 concentrations were evident (P < 0.05 for all). There was no effect of the high-fat meal on PlGF, TNF-a, or RBP4 concentrations. We found lower leptin concentrations with prior exercise (P < 0.05) and interactive effects of prior exercise and the high-fat meal on sFlt-1 (P < 0.05). The high-fat meal increased IL-6 by 59% without prior exercise and 218% with prior exercise (P < 0.05). In conclusion, a prior bout of endurance exercise does not affect all high-fat meal–induced changes in circulating cytokines, but does affect fasting or postprandial concentrations of IL-6, leptin, and sFlt-1. These data may reflect a salutary effect of prior exercise on metabolic responses to a high-fat meal.

Copyright Note

This is the publisher's version of the work. This publication appears in Gettysburg College's institutional repository by permission of the copyright owner for personal use, not for redistribution.

DOI

10.1002/phy2.40

Recommended Citation

Brandauer, Josef, et al. "Effects of Prior Acute Exercise on Circulating Cytokine Concentration Responses to a High-fat Meal," Physiological Reports 1.3 (August 2013), 1-10.

Required Publisher's Statement

Original version available from the publisher at: http://onlinelibrary.wiley.com/doi/10.1002/phy2.40/abstract