Dichloroacetate Inhibits Proliferation and Aerobic Glycolysis in B16-F10 Mouse Melanoma Cells

Mark A. Mednikov, Gettysburg College

Description

To test the effectiveness of dichloroacetate, a known Pyruvate Dehydrogenase Kinase inhibitor, as a method of slowing down the proliferation of cancerous cells as well as forcing them from aerobic glycolysis towards oxidative phosphorylation as their main energy source.

 
Apr 29th, 4:30 PM Apr 29th, 6:15 PM

Dichloroacetate Inhibits Proliferation and Aerobic Glycolysis in B16-F10 Mouse Melanoma Cells

CUB Ballroom

To test the effectiveness of dichloroacetate, a known Pyruvate Dehydrogenase Kinase inhibitor, as a method of slowing down the proliferation of cancerous cells as well as forcing them from aerobic glycolysis towards oxidative phosphorylation as their main energy source.